Early PET/CT Scan Is More Effective Than Response Evaluation Criteria In Solid Tumors in Predicting Outcome of Patients with Liver Metastases from Colorectal Cancer Treated with Preoperative Chemotherapy Plus Bevacizumab
نویسندگان
چکیده
1Nuclear Medicine Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Naples, Italy; 2Clinical Trials Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Naples, Italy; 3Abdominal Oncology Department, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Naples, Italy; 4Radiology 2 Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Naples, Italy; 5Pathology Department, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Naples, Italy; 6Epato-Biliary Surgery Unit, Istituto Nazionale Tumori “Fondazione G. Pascale” – IRCCS, Naples, Italy; and 7Medical Statistics, Second University of Napoli, Napoli, Italy
منابع مشابه
18FDG-PET evaluation correlates better than CT with pathological response in a metastatic colon cancer patient treated with bevacizumab-based therapy.
Around 20-30% of patients with hepatic metastasis from colorectal cancer can undergo liver resection, but the increased response rate obtained with the addition of monoclonal antibodies to chemotherapy regimens could result in a higher rate of liver surgery. In this report we describe the case of a patient who underwent a liver resection after neoadjuvant treatment with capecitabine, oxaliplati...
متن کاملAssociation of computed tomography morphologic criteria with pathologic response and survival in patients treated with bevacizumab for colorectal liver metastases.
CONTEXT The standard criteria used to evaluate tumor response, the Response Evaluation Criteria in Solid Tumors (RECIST), were developed to assess tumor shrinkage after cytotoxic chemotherapy and may be limited in assessing response to biologic agents, which have a cytostatic mechanism of action. OBJECTIVE To validate novel tumor response criteria based on morphologic changes observed on comp...
متن کاملEarly Assessment of Colorectal Cancer Patients with Liver Metastases Treated with Antiangiogenic Drugs: The Role of Intravoxel Incoherent Motion in Diffusion-Weighted Imaging
PURPOSE To assess the feasibility and effectiveness of quantitative intravoxel incoherent motion (IVIM) of Diffusion-weighted imaging (DWI) in the assessment of liver metastases treated with targeted chemotherapy agents. METHODS 12 patients with unresectable liver metastases from colorectal cancer were enrolled and received neoadjuvant FOLFIRI (5-fluorouracil, leucovorin, irinotecan) plus bev...
متن کاملValidation of several SUV-based parameters derived from 18F-FDG PET for prediction of survival after SIRT of hepatic metastases from colorectal cancer.
UNLABELLED (90)Y radioembolization (selective internal radiation therapy [SIRT]) is a valuable therapeutic option for unresectable hepatic metastases arising from primary colorectal cancer. The present study evaluated the prognostic value of (18)F-FDG PET/CT metabolic parameters for predicting survival after SIRT. METHODS Eighty patients with hepatic metastases of colorectal cancer were treat...
متن کاملFLT-PET for early response evaluation of colorectal cancer patients with liver metastases: a prospective study
BACKGROUND Fluoro-L-thymidine (FLT) is a positron emission tomography/computed tomography (PET/CT) tracer which reflects proliferative activity in a cancer lesion. The main objective of this prospective explorative study was to evaluate whether FLT-PET can be used for the early evaluation of treatment response in colorectal cancer patients (CRC) with liver metastases. Patients with metastatic C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013